The topic of the present paper subscribes to one of the most challenging themes that are nowadays under the spotlight of the scientific community. It describes a substantiated method aimed not only at predicting accurately the consequences of the associated effects of navigation in waves but also at contributing to ruling the conditions in which the operation of a ship should be performed is presented. A series of multiple degrees of freedom (DOF hereafter) simulations of the MOERI (Korea Research Institute for Ships and Ocean Engineering) container ship (KCS hereafter) hull moving in regular waves are performed and thoroughly validated with the experimental data provided by the organizers of the Tokyo 2015 Workshop on CFD in Ship Hydrodyna...