Aproximadamente 30% dos genes de organismos eucarióticos e procarióticos codificam para proteínas de membrana, e aproximadamente 60% dos alvos para o desenvolvimento de novas drogas são proteínas de membrana. Apesar disso, as proteínas de membrana correspondem a apenas cerca de 3% das estruturas depositadas no PDB. Os trocadores de Na++/Ca2+ (NCX) são proteínas de membrana absolutamente essenciais para a manutenção da homeostase de Ca2+ em diferentes tipos de células. Eles são formados por 10 hélices transmembranares e uma grande alça citoplasmática. O domínio transmembranar é responsável pelo transporte de Na+ e Ca2+ através da bicamada lipídica, enquanto a alça intracelular é responsável pela regulação alostérica do trocador por Ca2+ intr...
The three Na+/Ca2+ exchanger isoforms, NCX1, NCX2, and NCX3, contain a large cytoplasmic loop that i...
Contains fulltext : 36030.pdf (publisher's version ) (Closed access)The plasma mem...
Contains fulltext : 159868.pdf (publisher's version ) (Open Access)RU Radboud Univ...
O trocador de Na+/Ca2+ (NCX) constitui um dos principais mecanismos de extrusão de Ca2+ intracelular...
Proteínas de membrana estão envolvidas em processos fisiológicos essenciais como, por exemplo, a man...
ilustraciones, diagramas, tablasLos intercambiadores de sodio-calcio (Na+ /Ca2+ exchangers, NCX) com...
SummaryThe Na+/Ca2+ exchanger CALX promotes Ca2+ efflux in Drosophila sensory neuronal cells to faci...
Na(+)/Ca(2+) exchangers (NCX) constitute a major Ca(2+) export system that facilitates the re-establ...
Na+/Ca2+ exchanger (NCX) proteins mediate Ca2+-fluxes across the cell membrane to maintain Ca2+ home...
<div><p>Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) proteins mediate Ca<sup>2+</sup>-fluxes acros...
The Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) is a ubiquitous single-chain membrane protein tha...
Contains fulltext : 36511.pdf (publisher's version ) (Closed access)Binding of Na+...
The Na^+-Ca^(2+) exchanger from Drosophila was expressed in Xenopus and characterized electrophysiol...
The Na(+)-Ca2+ exchanger from Drosophila was expressed in Xenopus and characterized electrophysiolog...
Here we provide the first genome-wide in vivo analysis of the Na+/Ca2+ exchanger family in the model...
The three Na+/Ca2+ exchanger isoforms, NCX1, NCX2, and NCX3, contain a large cytoplasmic loop that i...
Contains fulltext : 36030.pdf (publisher's version ) (Closed access)The plasma mem...
Contains fulltext : 159868.pdf (publisher's version ) (Open Access)RU Radboud Univ...
O trocador de Na+/Ca2+ (NCX) constitui um dos principais mecanismos de extrusão de Ca2+ intracelular...
Proteínas de membrana estão envolvidas em processos fisiológicos essenciais como, por exemplo, a man...
ilustraciones, diagramas, tablasLos intercambiadores de sodio-calcio (Na+ /Ca2+ exchangers, NCX) com...
SummaryThe Na+/Ca2+ exchanger CALX promotes Ca2+ efflux in Drosophila sensory neuronal cells to faci...
Na(+)/Ca(2+) exchangers (NCX) constitute a major Ca(2+) export system that facilitates the re-establ...
Na+/Ca2+ exchanger (NCX) proteins mediate Ca2+-fluxes across the cell membrane to maintain Ca2+ home...
<div><p>Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) proteins mediate Ca<sup>2+</sup>-fluxes acros...
The Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) is a ubiquitous single-chain membrane protein tha...
Contains fulltext : 36511.pdf (publisher's version ) (Closed access)Binding of Na+...
The Na^+-Ca^(2+) exchanger from Drosophila was expressed in Xenopus and characterized electrophysiol...
The Na(+)-Ca2+ exchanger from Drosophila was expressed in Xenopus and characterized electrophysiolog...
Here we provide the first genome-wide in vivo analysis of the Na+/Ca2+ exchanger family in the model...
The three Na+/Ca2+ exchanger isoforms, NCX1, NCX2, and NCX3, contain a large cytoplasmic loop that i...
Contains fulltext : 36030.pdf (publisher's version ) (Closed access)The plasma mem...
Contains fulltext : 159868.pdf (publisher's version ) (Open Access)RU Radboud Univ...