This paper presents a lifetime reliability-based approach to the optimization of reinforced concrete (RC) cross-sections in an aggressive environment. The lifetime structural performance is evaluated by using a general methodology for time-variant analysis of RC structures subjected to diffusive attacks from aggressive agents with corrosion of the reinforcement. The lifetime probabilistic optimization is formulated at the cross-sectional level and is aimed to minimize the material cost under a time-dependent constraint on the structural reliability. The optimization problem is solved by combining a discrete gradient-based optimization method with a Monte Carlo simulation. The obtained results demonstrate that in a lifetime-oriented design t...