Regulatory T cells (Treg) are one of the major immunosuppressive cell subsets in the pancreatic tumor microenvironment. Tregs influence tumor growth by acting either directly on cancer cells or via the inhibition of effector immune cells. Treg cells mechanisms form a partially redundant network with other immunosuppressive cells such as myeloid-derived suppressor cells (MDSC) that confer robustness to tumor immunosuppression and resistance to immunotherapy. The results obtained in preclinical studies where after Treg depletion, MDSCs concomitantly decreased in early tumors whereas an inverse association was seen in advanced PCa, urge a comprehensive analysis of the immunosuppressive profile of PCa throughout tumorigenesis. One relevant cont...
Pancreatic ductal adenocarcinoma (PDA) is marked by an abundant fibroinflammatory microenvironment. ...
IMPORTANCE OF THE FIELD: The active suppression of immune responses against tumor is a major barrier...
Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the ...
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contr...
Recent years have seen significant efforts in understanding and modulating the immune response in ca...
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a poorly immunogenic cancer type that co...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
International audiencePancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising inciden...
Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the im...
Regulatory T cells (Tregs) represent a low number of T-cell population under normal conditions, and ...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
Active suppression of tumour-reactive T cells can limit both immune surveillance and immunotherapy. ...
Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal adenocarc...
The high progression rate of Pancreatic Ductal Adenocarcinoma (PDAC) depends on intrinsic genetic an...
Pancreatic ductal adenocarcinoma (PDA) is marked by an abundant fibroinflammatory microenvironment. ...
IMPORTANCE OF THE FIELD: The active suppression of immune responses against tumor is a major barrier...
Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the ...
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contr...
Recent years have seen significant efforts in understanding and modulating the immune response in ca...
Pancreatic ductal adenocarcinoma (PDAC) is considered to be a poorly immunogenic cancer type that co...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
International audiencePancreatic ductal adenocarcinoma (PDAC) is a fatal disease with rising inciden...
Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the im...
Regulatory T cells (Tregs) represent a low number of T-cell population under normal conditions, and ...
CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies h...
Active suppression of tumour-reactive T cells can limit both immune surveillance and immunotherapy. ...
Regulatory T (Treg) cell infiltration constitutes a prominent feature of pancreatic ductal adenocarc...
The high progression rate of Pancreatic Ductal Adenocarcinoma (PDAC) depends on intrinsic genetic an...
Pancreatic ductal adenocarcinoma (PDA) is marked by an abundant fibroinflammatory microenvironment. ...
IMPORTANCE OF THE FIELD: The active suppression of immune responses against tumor is a major barrier...
Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play an essential role in the ...