Physiological and pathological processes including embryogenesis and tumorigenesis rely on the ability of individual cells to work collectively to form multicell patterns. In these heterogeneous multicell systems, cell-cell signaling induces differential adhesion between cells that leads to tissue-level patterning. However, the sensitivity of pattern formation to changes in the strengths of signaling or cell adhesion processes is not well understood. Prior work has explored these issues using synthetically engineered heterogeneous multicell spheroid systems, in which cell subpopulations engage in bidirectional intercellular signaling to regulate the expression of different cadherins. While engineered cell systems provide excellent experimen...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
During embryonic development, the behavior of individual cells must be coordinated to create the lar...
The actions of cell adhesion molecules, in particular, cadherins during embryonic development and mo...
The actions of cell adhesion molecules, in particular, cadherins during embryonic development and mo...
A common theme in the self-organization of multicellular tissues is the use of cell-cell signaling n...
Cell adhesion refers to the ability of cells to make enduring and dynamic attachments to extracellul...
Pluripotent embryonic stem cells (ESCs) can differentiate into all somatic cell types, making them a...
Embryonic morphogenesis is a critical determinant of tissue generation and function, yet many of the...
BACKGROUND: To investigate how patterns of cell differentiation are related to underlying intra- and...
Animal development entails the organization of specific cell types in space and time, and spatial pa...
Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal tr...
Embryonic development depends on the precise coordination of cell fate specification, patterning and...
Human pluripotent stem cells (hPSCs) have the intrinsic ability to self-organize into complex multic...
To form patterns in vivo or in vitro, cells must carefully coordinate their behavior. Here I will pr...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
During embryonic development, the behavior of individual cells must be coordinated to create the lar...
The actions of cell adhesion molecules, in particular, cadherins during embryonic development and mo...
The actions of cell adhesion molecules, in particular, cadherins during embryonic development and mo...
A common theme in the self-organization of multicellular tissues is the use of cell-cell signaling n...
Cell adhesion refers to the ability of cells to make enduring and dynamic attachments to extracellul...
Pluripotent embryonic stem cells (ESCs) can differentiate into all somatic cell types, making them a...
Embryonic morphogenesis is a critical determinant of tissue generation and function, yet many of the...
BACKGROUND: To investigate how patterns of cell differentiation are related to underlying intra- and...
Animal development entails the organization of specific cell types in space and time, and spatial pa...
Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal tr...
Embryonic development depends on the precise coordination of cell fate specification, patterning and...
Human pluripotent stem cells (hPSCs) have the intrinsic ability to self-organize into complex multic...
To form patterns in vivo or in vitro, cells must carefully coordinate their behavior. Here I will pr...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
Eph receptors, the largest family of receptor tyrosine kinases, control cell-cell adhesion/de-adhesi...
During embryonic development, the behavior of individual cells must be coordinated to create the lar...