The evaluation of the best system-level architecture in terms of energy and performance is of mainly importance for a broad range of embedded SOC platforms. In this paper, we address the problem of the efficient exploration of the architectural design space for parameterized microprocessor-based systems. The architectural design space is multi-objective, so our aim is to find all the Pareto-optimal configurations representing the best power-performance design trade-offs by varying the architectural parameters of the target system. In particular, the paper presents a Design Space Exploration (DSE) framework tuned to efficiently derive Pareto-optimal curves. The main characteristics of the proposed framework consist of its flexibility and mod...