Considers reconfigurable computing for application-specific systems, with particular reference to mixed-technology chips. A VLIW "core" is augmented by means of reconfigurable functional units (RFUs) and register files implemented via FPGA on to the same chip. The application is analyzed to extract segments of computation that could be usefully collapsed into complex instructions decoded and executed by the RFUs. In this paper, we focus on the problem of selecting the optimum extension to the native instruction set by means of the "best" segments of the computation that will become complex instructions. In particular, a genetic algorithm approach is introduced to analyze the population of candidates; modifications to the classic genetic ope...