Dextrose prolotherapy for chronic tendinopathy: A scoping review

Introduction: Tendinopathy is a frequent source of musculoskeletal pain and disability. Between treatment options, prolotherapy, an injection treatment that aims to promote tissue healing, could play a role in symptomatic and functional improvement. The purpose of the study is to analyze current evidence about the effect of dextrose injections on clinical outcomes in patients with chronic tendinopathy. Methods: A literature search on MEDLINE (PubMed) and PEDro databases was conducted. All randomized controlled trials (RCTs) published in the last 10 years, with available abstracts, in English language, analyzing the effect of prolotherapy in human subjects with a diagnosis of chronic tendinopathy were considered. Methodological quality was assessed by PEDRO scale quality assessment tool. Results: Sixteen papers were included. Most of the RCTs were of medium to high quality. Based on the analyzed data, prolotherapy could represent an easy to access, cheap, safe and effective conservative treatment in rotator cuff tendinopathy and in epiconodylosis and could improve pain control in the medium to long-term, with encouraging data on function restoring in the long term. However, solutions preparation, procedural aspects and comparators were highly heterogeneous. Conclusion: Current evidence suggests that prolotherapy can results in improving symptoms in patients with tendinopathy, with no observed adverse reactions. However, few RCTs have been conducted; the results are not consistent enough and have a wide heterogeneity in their protocols so comparing data was not always possible. Therefore, further studies require a repeatable standardized procedure to confirm these positive preliminary results