We analyzed the genomes of 170 C. parapsilosis isolates and identified multiple copy number variations (CNVs). We identified two genes, RTA3 (CPAR2_104610) and ARR3 (CPAR2_601050), each of which was the target of multiple independent amplification events. Phylogenetic analysis shows that most of these amplifications originated only once. For ARR3, which encodes a putative arsenate transporter, 8 distinct CNVs were identified, ranging in size from 2.3 kb to 10.5 kb with 3 to 23 copies. For RTA3, 16 distinct CNVs were identified, ranging in size from 0.3 kb to 4.5 kb with 2 to ~50 copies. One unusual amplification resulted in a DUP-TRP/INV-DUP structure similar to some human CNVs. RTA3 encodes a putative phosphatidylcholine (PC) floppase whic...
Candida parapsilosis is an increasingly important opportunistic human pathogen, responsible for both...
The human pathogenic yeastCandida parapsilosishas gained significant importance over the past decade...
Antifungal resistance is an inevitable phenomenon when fungal pathogens are exposed to antifungal dr...
ABSTRACT Candida parapsilosis is an opportunistic fungal pathogen with increasing incidence in hospi...
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Can...
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Can...
In a collection of 395 independent clinical isolates classified as Candida parapsilosis on a biochem...
Candida parapsilosis is an emerging fungal pathogen and a leading cause of hospital-acquired bloodst...
PubMed: 31209012There are only a few antifungal drugs used systemically in treatment, and invasive f...
Candida metapsilosis is a rarely-isolated, opportunistic pathogen that belongs to a clade of pathoge...
Candida parapsilosis is an important nosocomial opportunistic pathogen, second in frequency only to ...
The application of randomly amplified polymorphic DNA (RAPD) technology for strain delineation of me...
Multidrug resistance (MDR) has emerged in hospitals due to the use of several agents administered in...
The genetic heterogeneity and antifungal susceptibility patterns of Candida parapsilosis isolated fr...
Candida parapsilosis is the second or third most common cause of candidemia in many countries. The I...
Candida parapsilosis is an increasingly important opportunistic human pathogen, responsible for both...
The human pathogenic yeastCandida parapsilosishas gained significant importance over the past decade...
Antifungal resistance is an inevitable phenomenon when fungal pathogens are exposed to antifungal dr...
ABSTRACT Candida parapsilosis is an opportunistic fungal pathogen with increasing incidence in hospi...
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Can...
Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Can...
In a collection of 395 independent clinical isolates classified as Candida parapsilosis on a biochem...
Candida parapsilosis is an emerging fungal pathogen and a leading cause of hospital-acquired bloodst...
PubMed: 31209012There are only a few antifungal drugs used systemically in treatment, and invasive f...
Candida metapsilosis is a rarely-isolated, opportunistic pathogen that belongs to a clade of pathoge...
Candida parapsilosis is an important nosocomial opportunistic pathogen, second in frequency only to ...
The application of randomly amplified polymorphic DNA (RAPD) technology for strain delineation of me...
Multidrug resistance (MDR) has emerged in hospitals due to the use of several agents administered in...
The genetic heterogeneity and antifungal susceptibility patterns of Candida parapsilosis isolated fr...
Candida parapsilosis is the second or third most common cause of candidemia in many countries. The I...
Candida parapsilosis is an increasingly important opportunistic human pathogen, responsible for both...
The human pathogenic yeastCandida parapsilosishas gained significant importance over the past decade...
Antifungal resistance is an inevitable phenomenon when fungal pathogens are exposed to antifungal dr...