This study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, and these results are parts of the Grant No. 451-03-68/2022-14/200132 with University of Kragujevac - Faculty of Technical Sciences Čačak.The aim of this work is to show the simulation of the nuclear decay of Iodine isotopes using the Mathematica software package. The nuclear decay of Iodine occurs most often during nuclear accidents in various types of nuclear facilities, during which radioactive isotopes are produced. Radioactive Iodine isotopes lead to the manifestation of harmful side effects, but with the development of science, it has been established that some of them can be used for diagnostic purposes and to detec...