Pulmonary Function and Blood DNA Methylation: A Multi-Ancestry Epigenome-Wide Association Meta-Analysis
- Lee, Mikyeong
- Huan, Tianxiao
- McCartney, Daniel L
- Chittoor, Geetha
- de Vries, Maaike
- Lahousse, Lies
- Nguyen, Jennifer N
- Brody, Jennifer A
- Castillo-Fernandez, Juan
- Terzikhan, Natalie
- Qi, Cancan
- Joehanes, Roby
- Min, Josine L
- Smilnak, Gordon J
- Shaw, Jessica R
- Yang, Chen Xi
- Colicino, Elena
- Hoang, Thanh T
- Bermingham, Mairead L
- Xu, Hanfei
- Justice, Anne E
- Xu, Cheng-Jian
- Rich, Stephen S
- Cox, Simon R
- Vonk, Judith M
- Prokić, Ivana
- Sotoodehnia, Nona
- Tsai, Pei-Chien
- Schwartz, Joel D
- Leung, Janice M
- Sikdar, Sinjini
- Walker, Rosie M
- Harris, Sarah E
- van der Plaat, Diana A
- Van Den Berg, David J
- Bartz, Traci M
- Spector, Tim D
- Vokonas, Pantel S
- Marioni, Riccardo E
- Taylor, Adele M
- Liu, Yongmei
- Barr, R Graham
- Lange, Leslie A
- Baccarelli, Andrea A
- Obeidat, Ma'en
- Fornage, Myriam
- Wang, Tianyuan
- Ward, James M
- Koppelman, Gerard H
- Boezen, H Marike
- London, Stephanie J
DOIAbstract
RATIONALE: Methylation integrates factors present at birth and modifiable across life that can influence pulmonary function. Studies are limited in scope and replication. OBJECTIVES: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. METHODS: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multi-ancestry epigenome-wide meta-analyses (17,503 individuals: 14,761 European; 2,549 African; and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. MEASUREMENTS AND MAIN RESULTS: We identified 1,267 CpGs (1,042 genes) differentially meth...
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