Amyloid-like motifs in short N-termini of NLRs.

Clusters of N-termini containing sequences resembling bacterial amyloid signaling motifs were identified using a probabilistic grammatical model [52]. Motifs were extracted with MEME [88] and iteratively refined with profile HMMs. (a) Profile HMM-based motif logos—grouped according to overlapping hits in NLR N-termini, as shown in panel (b) Overlapping hits in NLR N-termini. See Results and Methods for details. (c) Stacked histogram of motif hits positions in NLR N-termini for the five largest motif families, color-coded as in panel (a)).