OBJECTIVE: We investigated the cause of recurring tuberculosis (rcTB) among pulmonary TB participants recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools in addition to whole genome sequencing, followed by phylogenetic analysis to assess strain relatedness. RESULTS: A greater proportion (58.3%, 21/36) of individuals with rcTB episodes had TB recurrence within 12 months post treatment. Only 19.4% (7/36) of participants with rcTB harbored a strain with isoniazid (INH) resistance at baseline of which 29% (2/7) were additionally resistant to rifampicin. However...
Tuberculosis (TB) remains a public health challenge. In 2013, TB was estimated to have caused 9 mill...
Abstract Background The recurrence of tuberculosis (TB) disease in treated patients can serve as a m...
To improve understanding of the factors influencing tuberculosis transmission and the role of pathog...
BACKGROUND: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is c...
Understanding transmission dynamics is useful for tuberculosis (TB) control. A population-based mole...
Whole genome sequencing (WGS) is progressively being used to investigate the transmission dynamics o...
BACKGROUND: Recurrent tuberculosis is a major health burden and may be due to relapse with the origi...
Background: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in bot...
SummaryBackgroundRecurrence of tuberculosis after treatment makes management difficult and is a key ...
OBJECTIVE: To estimate rates of recurrent tuberculosis due to reinfection and relapse, by HIV status...
BACKGROUND: There is a perception that genomic differences in the species/lineages of the nine speci...
Background. Recurrent tuberculosis is a major health burden and may be due to relapse with the origi...
BackgroundBovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both l...
SETTING: A gold mine in South Africa. OBJECTIVE: To investigate incidence and risk factors for tuber...
BACKGROUND:Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both ...
Tuberculosis (TB) remains a public health challenge. In 2013, TB was estimated to have caused 9 mill...
Abstract Background The recurrence of tuberculosis (TB) disease in treated patients can serve as a m...
To improve understanding of the factors influencing tuberculosis transmission and the role of pathog...
BACKGROUND: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is c...
Understanding transmission dynamics is useful for tuberculosis (TB) control. A population-based mole...
Whole genome sequencing (WGS) is progressively being used to investigate the transmission dynamics o...
BACKGROUND: Recurrent tuberculosis is a major health burden and may be due to relapse with the origi...
Background: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in bot...
SummaryBackgroundRecurrence of tuberculosis after treatment makes management difficult and is a key ...
OBJECTIVE: To estimate rates of recurrent tuberculosis due to reinfection and relapse, by HIV status...
BACKGROUND: There is a perception that genomic differences in the species/lineages of the nine speci...
Background. Recurrent tuberculosis is a major health burden and may be due to relapse with the origi...
BackgroundBovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both l...
SETTING: A gold mine in South Africa. OBJECTIVE: To investigate incidence and risk factors for tuber...
BACKGROUND:Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both ...
Tuberculosis (TB) remains a public health challenge. In 2013, TB was estimated to have caused 9 mill...
Abstract Background The recurrence of tuberculosis (TB) disease in treated patients can serve as a m...
To improve understanding of the factors influencing tuberculosis transmission and the role of pathog...