Resveratrol, Multiple Bioactivities for a Wide Range of Health Benefits. New Innovative Extracts for Nutraceutical, Pharmaceutical, and Cosmetics Applications

Resveratrol (trans-resveratrol or 3,4′,5-trihydroxystilbene) is a polyphenol naturally present in grape skin and seeds. New innovative concentrated extracts produced by microorganisms or with innovative, ecological extraction techniques allow a new generation of high-quality ingredients for a diversity of product applications in nutraceuticals, cosmetics, and pharmaceuticals. Resveratrol exerts antioxidant and anti-inflammatory properties while promoting sirtuins 1 activities and mitochondrial functions. It also modulates multiple cellular signaling molecules, such as VEGF, caspases, cytokines NF-kB, vascular cell adhesion molecule, IGF-1, PPARs, and COX-2. Its clinical benefits have been demonstrated mainly in cognitive health, menopause, bone health, cardiovascular health, glucose metabolism, sport nutrition, and skin health. This chapter reviews the bioactivities of resveratrol, its clinical benefits, and detail its potential applications in several product categories in the growing field of health and nutrition product innovation. Resveratrol-based products may participate to provide new natural and complementary solutions for a global approach to health support and maintenance