Doxorubicin-induced oxidative stress injury: The protective effect of kumiss on cardiotoxicity

© 2022, Seval YILMAZ, Emre KAYA, Harun YONAR, Ali Sefa MENDILDoxorubicin (DOX), which is used in cancer treatment, is an effective chemotherapy agent with many side effects. Cardiotoxicity, on the other hand, is the most important side effect, and it has pushed us to work with kumiss, an alcoholic beverage made from mare’s milk, rich in fermentates, trace elements, antibiotics, vitamins, ethyl alcohol, lactic acid and carbonic acid. The aim of this study was to investigate the effect of kumiss on cardiotoxicity caused by DOX. Twenty-eight Wistar-Albino male rats were divided into 4 groups: There was no intervention in the first group (control). The second group received 2 ml/kg/day of kumiss by gavage needle for 7 days, a single dose of 20 mg/kg, intraperitoneal DOX to the third group, and kumiss+DOX to the fourth group. Kumiss application was started 7 days before DOX administration and continued for 7 days. On the 7th day of kumiss application, DOX was administered intraperitoneally. The malondialdehyde (MDA), reduced glutathione (GSH) levels and antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PD) and glutathione-S-transferase (GST) activities were determined in order to determine their effectiveness in the pathogenesis of cardiotoxicity in cardiac and blood tissues. When the DOX group was compared with the control group, an increase in MDA (p<0.001, p<0.001) and GSH (p<0.001, p=0.002) levels and a decrease in CAT (p=0.001, p<0.001), GSH-Px (p<0.001, p<0.001), G6PD (p