THE EVOLUTION OF NOVEL ISATIN DERIVATIVES TO IMPROVE ANTIBACTERIAL ACTIVITY : Antibacterial activity of Isatin derivatives

Objective: The main objective of the present investigation is to design, synthesize and evaluate isatin derivatives for their possible antibacterial activities.   Methods: In this research article, some new spiro derivatives of isatin were synthesized by two different pathways. The chalcones were prepared by the reaction of different acetophenones and isatins via base-catalyzed condensation followed by the addition of acid. The compounds have been characterized by UV-Vis, FT-IR, 1H-NMR,13C-NMR, and Mass spectra.   Result: It was found that the compounds exhibited moderate to significant antibacterial action against 5 various bacterial strains i.e., Salmonella typhi, Bacillus subtilus, Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. The action of all compounds was compared with standard drug i.e., Streptomycin.   Conclusions: It was concluded that all synthesized Isatin derivatives are useful for giving antibacterial responses for one or other bacterial strains. Their action was compared with the standard drug and found that IP1 showed a response that it was almost the same as streptomycin effects against S. Typhi. &nbsp