In normal tissues, the processes of growth, remodeling, and morphogenesis are tightly regulated by the stress field; conversely, stress may be generated by these processes. We demonstrate that solid stress inhibits tumor growth in vitro, regardless of host species, tissue of origin, or differentiation state. The inhibiting stress for multicellular tumor spheroid growth in agarose matrices was 45 to 120 mm Hg. This stress, which greatly exceeds blood pressure in tumor vessels, is sufficient to induce the collapse of vascular or lymphatic vessels in tumors in vivo and can explain impaired blood flow, poor lymphatic drainage, and suboptimal drug delivery previously reported in solid tumors. The stress-induced growth inhibition of plateau-phase...
The experimental evidence that a feedback exists between growth and stress in tumors poses challengi...
<div><p>Growing solid tumors are subjected to mechanical stress that influences their growth rate an...
<div><p></p><p>Solid stresses emerge as the expanding tumor displaces and deforms the surrounding no...
In normal tissues, the processes of growth, remodeling, and morphogenesis are tightly regulated by t...
The unchecked growth of a solid tumor produces solid stress, causing deformation of the surrounding ...
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these ...
AbstractIn most instances, the growth of solid tumors occurs in constrained environments and require...
Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor ...
Background: Compressive mechanical stress produced during growth in a confining matrix limits the si...
International audienceIn most instances, the growth of solid tumors occurs in constrained environmen...
International audienceThe precise role of the microenvironment on tumor growth is poorly understood....
In this study, we proposed an in vitro tumor model to simulate the mechanical microenvironment and i...
<div><p>Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells...
Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibit...
Mechanical stress accumulating during growth in solid tumors plays a crucial role in the tumor mecha...
The experimental evidence that a feedback exists between growth and stress in tumors poses challengi...
<div><p>Growing solid tumors are subjected to mechanical stress that influences their growth rate an...
<div><p></p><p>Solid stresses emerge as the expanding tumor displaces and deforms the surrounding no...
In normal tissues, the processes of growth, remodeling, and morphogenesis are tightly regulated by t...
The unchecked growth of a solid tumor produces solid stress, causing deformation of the surrounding ...
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these ...
AbstractIn most instances, the growth of solid tumors occurs in constrained environments and require...
Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor ...
Background: Compressive mechanical stress produced during growth in a confining matrix limits the si...
International audienceIn most instances, the growth of solid tumors occurs in constrained environmen...
International audienceThe precise role of the microenvironment on tumor growth is poorly understood....
In this study, we proposed an in vitro tumor model to simulate the mechanical microenvironment and i...
<div><p>Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells...
Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibit...
Mechanical stress accumulating during growth in solid tumors plays a crucial role in the tumor mecha...
The experimental evidence that a feedback exists between growth and stress in tumors poses challengi...
<div><p>Growing solid tumors are subjected to mechanical stress that influences their growth rate an...
<div><p></p><p>Solid stresses emerge as the expanding tumor displaces and deforms the surrounding no...