The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitted to a critical review starting from the early reports pointing to mitomycin C bioactivation and to the toxicity mechanisms of diepoxybutane and a group of nitrogen mustards causing DNA crosslinks in FA cells. A critical analysis of the literature prompts revisiting the FA phenotype and crosslinker sensitivity in terms of an oxidative stress (OS) background, redox-related anomalies of FA (FANC) proteins, and mitochondrial dysfunction. This re-appraisal of FA basic defect might lead to innovative approaches both in elucidating FA phenotypes and in clinical managemen
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defec...
Fanconi anemia (FA) is a rare genetic disease associated with deficiencies in DNA repair pathways. A...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitte...
The literature pointing to mitomycin C bioactivation, and to the toxicity mechanisms of diepoxybutan...
A review. Fanconi anemia (FA) is a genetic disease characterised by bone marrow failure with excess ...
Fanconi anemia (FA) is a recessively inherited disorder associated with developmental abnormalities,...
Fanconi anemia (FA) is a rare human recessive syndrome featuring bone marrow failure, myelodysplasia...
A review. Fanconi anemia (FA) is a genetic disease characterised by bone marrow failure with excess ...
Fanconi anemia (FA) is a rare genetic disease associated with deficiencies in DNA repair pathways. A...
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defec...
Fanconi anemia (FA) is a rare genetic disease associated with deficiencies in DNA repair pathways. A...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
The commonly accepted definition of Fanconi anemia (FA) relying on DNA repair deficiency is submitte...
The literature pointing to mitomycin C bioactivation, and to the toxicity mechanisms of diepoxybutan...
A review. Fanconi anemia (FA) is a genetic disease characterised by bone marrow failure with excess ...
Fanconi anemia (FA) is a recessively inherited disorder associated with developmental abnormalities,...
Fanconi anemia (FA) is a rare human recessive syndrome featuring bone marrow failure, myelodysplasia...
A review. Fanconi anemia (FA) is a genetic disease characterised by bone marrow failure with excess ...
Fanconi anemia (FA) is a rare genetic disease associated with deficiencies in DNA repair pathways. A...
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defec...
Fanconi anemia (FA) is a rare genetic disease associated with deficiencies in DNA repair pathways. A...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...