Sexual dichotomy exists in the development, presentation, and course of many neuropsychiatric disorders, including anxiety. Anxiety disorders are one of the earliest psychiatric illnesses to manifest and a role for immune system programming of the developing CNS has emerged in relation to anxiety. Adult rodents neonatally exposed to an immune challenge exhibit increased anxiety-related behaviors. The objective of this study was to determine the impact of postnatal immune challenge on behavior and microglia during the postnatal period and in adulthood. Mice were administered lipopolysaccharide (LPS; 0.05mg/kg, i.p.) or saline on postnatal days (P) three and five. Anxiety-related behavior was assessed during early development on P15 and P21, ...
Prenatal exposure to lipopolysaccharide (LPS), which likely occurs due to infection or contact with ...
Although it is well-established that the immune system plays an important role in the development of...
Early-life stress (ELS) can induce anxiety-like behaviors and social deficits in male and female rod...
It is well known that inflammatory challenge during the prenatal period results in permanent changes...
Sex-specific differences in behavior have been observed in anxiety and learning in children exposed ...
Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorder...
The present study examined the effects of neonatal (postnatal days 3 and 5) acute immune system acti...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour in adulthood. Our curren...
Pubertal development is a time of growth and development in the brain, leading to high sensitivity d...
Neonatal exposure of rodents to an immune challenge alters a variety of behavioural and physiologica...
Neurodevelopmental disorders manifest early and may impair function throughout life. Exposure to env...
Aim: Immune challenge during early and late neonatal periods can induce robust alterations in physio...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour and alters neuroendocrin...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour and alters neuroendocrin...
Neonatal exposure to an immune challenge has been shown to alter many facets of adult physiology inc...
Prenatal exposure to lipopolysaccharide (LPS), which likely occurs due to infection or contact with ...
Although it is well-established that the immune system plays an important role in the development of...
Early-life stress (ELS) can induce anxiety-like behaviors and social deficits in male and female rod...
It is well known that inflammatory challenge during the prenatal period results in permanent changes...
Sex-specific differences in behavior have been observed in anxiety and learning in children exposed ...
Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorder...
The present study examined the effects of neonatal (postnatal days 3 and 5) acute immune system acti...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour in adulthood. Our curren...
Pubertal development is a time of growth and development in the brain, leading to high sensitivity d...
Neonatal exposure of rodents to an immune challenge alters a variety of behavioural and physiologica...
Neurodevelopmental disorders manifest early and may impair function throughout life. Exposure to env...
Aim: Immune challenge during early and late neonatal periods can induce robust alterations in physio...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour and alters neuroendocrin...
Neonatal lipopolysaccharide (LPS) exposure increases anxiety-like behaviour and alters neuroendocrin...
Neonatal exposure to an immune challenge has been shown to alter many facets of adult physiology inc...
Prenatal exposure to lipopolysaccharide (LPS), which likely occurs due to infection or contact with ...
Although it is well-established that the immune system plays an important role in the development of...
Early-life stress (ELS) can induce anxiety-like behaviors and social deficits in male and female rod...