Add to ORKGA significant proportion of inflammatory bowel disease (IBD) patients are primary non-responders to biological therapies. Human Neutrophil Elastase (HNE) is highly expressed in IBD mucosa, especially in ulcerative colitis (UC). The aim of this study was to determine whether HNE degrades biologics, rendering them ineffective, and whether its action can be reversed by its natural inhibitor, Elafin.Instituto de Estudios Inmunológicos y Fisiopatológico
Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an e...
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are n...
Inflammatory bowel disease (IBD), a chronic and relapsing intestinal inflammation, affects about 3.6...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
[Background] Neutrophil elastase (NE) is a proteinase in granulocytes and plays an important role in...
International audienceImbalance between proteases and their inhibitors plays a crucial role in the d...
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut and comprises...
This thesis entitled “Gut mucosal gene expression in inflammatory bowel disease - the heterogeneous ...
Background: Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional pro...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of i...
BACKGROUND: We aim to identify the differences in colonic mucosal transcriptome between Crohn's dise...
BACKGROUND & AIMS: Colonic tissues of patients with inflammatory bowel disease have been reported to...
BACKGROUND & AIMS: Colonic tissues of patients with inflammatory bowel disease have been reported to...
Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an e...
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are n...
Inflammatory bowel disease (IBD), a chronic and relapsing intestinal inflammation, affects about 3.6...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
Purpose: Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD)...
[Background] Neutrophil elastase (NE) is a proteinase in granulocytes and plays an important role in...
International audienceImbalance between proteases and their inhibitors plays a crucial role in the d...
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut and comprises...
This thesis entitled “Gut mucosal gene expression in inflammatory bowel disease - the heterogeneous ...
Background: Inhibition of prolyl hydroxylases (PHDs) leads to the induction of a transcriptional pro...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of i...
BACKGROUND: We aim to identify the differences in colonic mucosal transcriptome between Crohn's dise...
BACKGROUND & AIMS: Colonic tissues of patients with inflammatory bowel disease have been reported to...
BACKGROUND & AIMS: Colonic tissues of patients with inflammatory bowel disease have been reported to...
Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an e...
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are n...
Inflammatory bowel disease (IBD), a chronic and relapsing intestinal inflammation, affects about 3.6...