信州大学医学部附属病院にて検出されたPseudomonas aeruginosa の薬剤感受性および感受性パターンによる分類

For empiric therapy against infections, it is most important to select antibiotics on the basis of statistical analyses of drug-resistance of the bacteria isolated in a hospital or a region. In this study, we examined the drug-resistance of Pseudomonas aeruginosa (P. aeruginosa) at Shinshu University Hospital from October 2000 to December 2002, and classified 502 isolates by antibiograms of 26 antibiotics. The vast majority of P. aeruginosa isolates showed good susceptiblity to piperacillin, 3rd generation cephalosporins, carbapenems, aminoglycosides, and quinolones. However, it should be noted that 2 isolates with multi-resistance to carbapenem, aminoglycoside and quinolone were included among the strains investigated. What is most interesting is the fact that 41 isolated were demonstrated to be resistant to 2 out of the 3 antibiotics mentioned above.The strains examined were classified according to their antibiogram into the isolates into 16 types and 168 subtypes.One of the 16 types was detected only in a particular department,and some subtypes were often observed in certain wards, thus indicating nosocomial infections.Analysis by antibiogram is a cost-effective method to classify the isolates, and is useful for monitoring the occurrence of drug-resistant isolates and outbreaks in a facility.Article信州医学雑誌 51(5): 281-288(2003)journal articl