Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection
- Joshita, Satoru
- Umemura, Takeji
- Katsuyama, Yoshihiko
- Ichikawa, Yuki
- Kimura, Takefumi
- Morita, Susumu
- Kamijo, Atsushi
- Komatsu, Michiharu
- Ichijo, Tetsuya
- Matsumoto, Akihiro
- Yoshizawa, Kaname
- Kamijo, Nozomi
- Ota, Masao
- Tanaka, Eiji
Publication date
March 2012
DOI Publisher
Elsevier BV Journal
Human Immunology Language
EnglishAbstract
IL28B single nucleotide polymorphisms (SNPs) are associated with spontaneous and treatment-induced elimination of hepatitis C virus (HCV). To assess whether the IL28B rs8099917 SNP also affects the progression of chronic HCV infection, we genotyped 511 Japanese HCV patients, including 69 with hepatocellular carcinoma (HCC). The T/T genotype of rs8099917 was not associated with the development of HCC (p = 0.623), although stepwise logistic regression analysis showed that liver cirrhosis, age greater than 68 years, and serum albumin <4.2 mg/dl were associated with HCC onset. It appears that the IL28B SNP does not directly influence hepatocarcinogenesis in chronic HCV infection.ArticleHUMAN IMMUNOLOGY. 73(3):298-300 (2012)journal articl
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