The role of inferior petrosal sinus sampling in ACTH-dependent Cushing's syndrome:review and joint opinion statement by members of the Italian Society for Endocrinology, Italian Society for Neurosurgery, and Italian Society for Neuroradiology
- Giraldi F
- Cavallo LM
- Tortora F
- Pivonello R
- Colao A
- Cappabianca P
- Mantero F
- Albiger N
- Alviggi C
- Ambrogio AG
- Arnaldi G
- Arvat E
- Baldelli R
- Boscaro M
- Campo M
- Cannavò S
- Cavagnini F
- Chiodini I
- Corsello SM
- Cozzolino A
- Di Leo M
- De Martino M
- , Di Somma C
- Esposito K
- Ferone D
- Gatto F
- Giordano R
- Giugliano D
- Graziadio C
- Grimaldi F
- Iacuaniello D
- Isidori A
- Karamouzis I
- Lenzi A
- Loli P
- Mannelli M
- Marzullo P
- Morelli V
- Paragliola RM
- Parenti G
- Pivolenno C
- Reimondo G
- Scaroni C
- Alfredo S
- Simeoli C
- Stigliano A
- Talco M
- Terzolo M
- Trementino L
- Urbani C
- Vitale G
- Zatelli MC
DOIAbstract
In the management of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome, inferior petrosal sinus sampling (IPSS) provides information for the endocrinologist, the neurosurgeon, and the neuroradiologist. To the endocrinologist who performs the etiological diagnosis, results of IPSS confirm or exclude the diagnosis of Cushing's disease with 80%-100% sensitivity and over 95% specificity. Baseline central-peripheral gradients have suboptimal accuracy, and stimulation with corticotropin-releasing hormone (CRH), possibly desmopressin, has to be performed. The rationale for the use of IPSS in this context depends on other diagnostic means, taking availability of CRH and reliability of dynamic testing and pituitary imaging into account...
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