Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
- Biava M
- Battilocchio C
- Poce G
- Alfonso S
- Consalvi S
- Porretta GC
- Schenone S
- Calderone V
- Martelli A
- Testai L
- Ghelardini C
- Di Cesare Mannelli L
- Giordani A
- Patrignani P
- Anzini M.
- SAUTEBIN, LIDIA
- ROSSI, ANTONIETTA
Publication date
January 2012
DOIAbstract
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds
Add to ORKG