Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation

  • CATALANOTTI, BRUNO
  • FATTORUSSO, CATERINA
  • MAYOL, LUCIANO
  • OLIVIERO, GIORGIA
  • PICCIALLI, GENNARO
  • VARRA, MICHELA
Publication date
January 2003

Abstract

Oligonucleotides with a 3'-3' inversion of polarity and containing an acridine group attached to nucleotide base flanking the 3'-3' phosphodiester bon have been synthesized, characterized and used as third strand in alternate triple helix formation. CD melting studies and molecular mechanics calculations have been carried out to investigate these triplex structures

Extracted data

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