New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity
- D'ATRI, VALENTINA
- OLIVIERO, GIORGIA
- AMATO, JUSSARA
- BORBONE, NICOLA
- D'ERRICO, STEFANO
- MAYOL, LUCIANO
- PICCIALLI, VINCENZO
- PICCIALLI, GENNARO
- Shozeb Haider
- Bart Hoorelbeke
- Jan Balzarini
DOIAbstract
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude
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