Thermodynamics of formation of inclusion compounds in water. α-Cyclodextrin-alcohol adducts at 298.15 K

The interaction in H2O of ROH (R = Et, Pr, Bu, CH2CHMe2, CHMeEt, CMe3) with α-cyclodextrin (I) was studied calorimetrically at 298.15 K. With the exception of the Me3COH, these ROH form inclusion complexes with I. The thermodn. parameters characterizing the binding process were detd. The complexes that result are weak, as shown by the low values of the consts. The abs. values of the heat of binding and the equil. const. (K'B) increase with increasing length of R. Branching of R lowers the value of K'B. Me3COH does not form a complex with I, probably because of steric hindrance. [on SciFinder(R)