Structure and absolute stereochemistry of the new cyclolinteinol and cyclolinteinol acetate, macrophage activation modulators

wo novel sesterterpenes, cyclolinteinol (5) and cyclolinteinol acetate (6), have been isolated from the Caribbean sponge Cacospongia cf. linteiformis. Their structures and absolute stereochemistry were determined using spectroscopic and chemical methods. The new compounds (5, 6) and the related compounds 1-3, previously isolated from the sponge, strongly inhibited NO production by LPS-stimulated murine macrophages J774