Genetic analysis of Down syndrome-associated heart defects in mice
- Liu C.
- Morishima M.
- Yu T.
- Matsui S.
- Zhang L.
- FU D.
- Pao A.
- Costa A.
- Gardiner K.
- Cowell J.
- Nowak N. J.
- Parmacek M. S.
- Liang P.
- Yu Y. E.
- BALDINI, ANTONIO
Publication date
January 2011
DOI Publisher
Springer Science and Business Media LLC ISSN
0340-6717 Citation count (estimate)
30Abstract
Human trisomy 21, the chromosomal basis of Down syndrome (DS), is the most common genetic cause of heart defects. Regions on human chromosome 21 (Hsa21) are syntenically conserved with three regions located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. In this study, we have analyzed the impact of duplications of each syntenic region on cardiovascular development in mice and have found that only the duplication on Mmu16, i.e., Dp(16)1Yey, is associated with heart defects
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