Synthesis and conformation of dipeptide taste ligands containing homo-B-amino acid residues

Interaction of sweet proteins with their receptor - A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin

Tancredi T
Salvadori S
Esposito V
Temussi PA
PASTORE, ANNALISA

January 2004

The mechanism of interaction of sweet proteins with the T1R2-T1R3 sweet taste receptor has not yet b...

Conformation of Aminosuccinyl Dipeptides Ac-l-x-l-asu-nme From Empirical Energy Calculations

CAPASSO, SANTE
SICA, FILOMENA
C. A. MATTIA
L. MAZZARELLA
A. ZAGARI

January 1992

The aminosuccinyl (Asu) residue is formed as intermediate in some peptide and protein reactions. Pot...

Bioactive and Model Peptides Characterized By the Helicogenic (alpha-me)phe Residue

TONIOLO, CLAUDIO
FORMAGGIO, FERNANDO
M. CRISMA
G. VALLE
W. H. J.
H. E. SCHOEMAKER
J. KAMPHUIS
P. A. TEMUSSI
E. L. BECKER
G. PRECIGOUX

January 1993

We have synthesized and fully characterized the hypersweet super-aspartame analogue pCN-C6H4-NHCO-L-...

Synthesis and conformation of dipeptide taste ligands containing homo-B-amino acid residues

C. ISERNIA
P. DI LELLO
R. IACOVINO
BUCCI, ENRICO
DE NAPOLI, LORENZO
MONTESARCHIO, DANIELA
PICCIALLI, GENNARO
ROSSI, FILOMENA
SAVIANO, Michele
BENEDETTI, ETTORE

January 1999

The synthesis and conformational properties of a series of dipeptide taste ligands, differing from t...

Synthesis and conformation of dipeptide taste ligands containing homo-β-amino acid residues

ISERNIA, Carla
BUCCI E.
DE NAPOLI L.
DI LELLO P.
IACOVINO, Rosa
MONTESARCHIO D.
PICCIALLI G.
ROSSI F.
SAVIANO M.
BENEDETTI E.

January 1999

The synthesis and conformational properties of a series of dipeptide taste ligands, differing from t...

Homo-beta-amino acid residues: synthesis and conformation of new dipeptide taste ligands

Benedetti E.
Bucci E.
De Napoli L.
Di Lello P.
Iacovino R.
Isernia C.
Montesarchio D.
Piccialli G.
Rossi F.
Saviano M.

January 1998

We found the L-shaped conformation of synthetic modified aspartame dipeptide . We have compared the ...

Conformational analysis of the dipeptide taste ligand L-aspartyl-D-2-aminobutyric acid-(S)-α-ethylbenzylamide and its analogues by NMR spectroscopy, computer simulations and X-ray diffraction studies

Goodman, M.
Zhu, Q.
Kent, D. R.
Amino, Y.
Benedetti, E.
Santini, A.
IACOVINO, Rosa

January 1997

A dipeptide taste ligand L-aspartyl-D-2-aminobutyric acid-(S)-α-ethylbenzylamide was found to be abo...

X-ray structures of new dipeptide taste ligands

MURRAY GOODMAN
RALPH HEIKO MATTERN
PETER GANTZEL ANTONELLO SANTINI
MICHELE SAVIANO AND ETTORE BENEDETTI
IACOVINO, Rosa

January 1998

The molecular basis of sweet taste was investigated by carrying out the crystal state conformational...

Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C-alpha-methylation in the second position

E., Mossel
Formaggio, Fernando
M., Crisma
Toniolo, Claudio
Q. B., Broxterman
W. H., J.
J., Kamphuis
P. J., L.
P., Temussi

January 1997

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartam...

Aspartame analogues containing 1-amino-2-phenylcyclohexanecarboxylic acids (c6Phe)

Avenoza, A.
París, M.
Peregrina, J.M.
Alías, M.
López, M.P.
García, J.I.
Cativiela, C.

January 2002

This report describes the synthesis and the conformational analysis of the optically pure dipeptides...

Conformationally Restricted Analogs of Antiaspartame-type Sweeteners

Formaggio, Fernando
M., Crisma
G., Valle
Toniolo, Claudio
W. H., J.
H. E., Schoemaker
J., Kamphuis
P. A., Temussi

January 1992

The synthesis and characterization of the two diastereomeric dipeptides Ac-L-(alphaMe)Phe-L-Lys-OH (...

Aspartame analogues containing 1-amino-2-phenylcyclohexanecarboxylic acids (c6Phe). Part 2

Alías, Miriam
Lasa, Marta
López, Pilar
García, José I.
Cativiela, Carlos

January 2005

This report describes the synthesis and conformational analysis of optically pure dipeptide analogue...

Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies.

A. De Capua
M. Goodman
Y. Amino
M. Saviano
BENEDETTI, ETTORE

January 2006

We report here the synthesis and the conformation analysis by 1H NMR spectroscopy and computer simul...

Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine

Mollica, Adriano
Mirzaie, Sarra
Costante, Roberto
Carradori, Simone
Macedonio, G.
Dvorácskó, Szabolcs

January 2016

The dipeptide aspartame (Asp-Phe-OMe) is a sweetener widely used in replacement of sucrose by food i...

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

Samir H. Bouayad-Gervais
William D. Lubell

November 2013

The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitro...

Interaction of sweet proteins with their receptor - A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin

Tancredi T
Salvadori S
Esposito V
Temussi PA
PASTORE, ANNALISA

January 2004

The mechanism of interaction of sweet proteins with the T1R2-T1R3 sweet taste receptor has not yet b...

Conformation of Aminosuccinyl Dipeptides Ac-l-x-l-asu-nme From Empirical Energy Calculations

CAPASSO, SANTE
SICA, FILOMENA
C. A. MATTIA
L. MAZZARELLA
A. ZAGARI

January 1992

The aminosuccinyl (Asu) residue is formed as intermediate in some peptide and protein reactions. Pot...

Bioactive and Model Peptides Characterized By the Helicogenic (alpha-me)phe Residue

TONIOLO, CLAUDIO
FORMAGGIO, FERNANDO
M. CRISMA
G. VALLE
W. H. J.
H. E. SCHOEMAKER
J. KAMPHUIS
P. A. TEMUSSI
E. L. BECKER
G. PRECIGOUX

January 1993

We have synthesized and fully characterized the hypersweet super-aspartame analogue pCN-C6H4-NHCO-L-...

Synthesis and conformation of dipeptide taste ligands containing homo-B-amino acid residues

C. ISERNIA
P. DI LELLO
R. IACOVINO
BUCCI, ENRICO
DE NAPOLI, LORENZO
MONTESARCHIO, DANIELA
PICCIALLI, GENNARO
ROSSI, FILOMENA
SAVIANO, Michele
BENEDETTI, ETTORE

January 1999

The synthesis and conformational properties of a series of dipeptide taste ligands, differing from t...

Synthesis and conformation of dipeptide taste ligands containing homo-β-amino acid residues

ISERNIA, Carla
BUCCI E.
DE NAPOLI L.
DI LELLO P.
IACOVINO, Rosa
MONTESARCHIO D.
PICCIALLI G.
ROSSI F.
SAVIANO M.
BENEDETTI E.

January 1999

The synthesis and conformational properties of a series of dipeptide taste ligands, differing from t...

Homo-beta-amino acid residues: synthesis and conformation of new dipeptide taste ligands

Benedetti E.
Bucci E.
De Napoli L.
Di Lello P.
Iacovino R.
Isernia C.
Montesarchio D.
Piccialli G.
Rossi F.
Saviano M.

January 1998

We found the L-shaped conformation of synthetic modified aspartame dipeptide . We have compared the ...

Conformational analysis of the dipeptide taste ligand L-aspartyl-D-2-aminobutyric acid-(S)-α-ethylbenzylamide and its analogues by NMR spectroscopy, computer simulations and X-ray diffraction studies

Goodman, M.
Zhu, Q.
Kent, D. R.
Amino, Y.
Benedetti, E.
Santini, A.
IACOVINO, Rosa

January 1997

A dipeptide taste ligand L-aspartyl-D-2-aminobutyric acid-(S)-α-ethylbenzylamide was found to be abo...

X-ray structures of new dipeptide taste ligands

MURRAY GOODMAN
RALPH HEIKO MATTERN
PETER GANTZEL ANTONELLO SANTINI
MICHELE SAVIANO AND ETTORE BENEDETTI
IACOVINO, Rosa

January 1998

The molecular basis of sweet taste was investigated by carrying out the crystal state conformational...

Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C-alpha-methylation in the second position

E., Mossel
Formaggio, Fernando
M., Crisma
Toniolo, Claudio
Q. B., Broxterman
W. H., J.
J., Kamphuis
P. J., L.
P., Temussi

January 1997

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartam...

Aspartame analogues containing 1-amino-2-phenylcyclohexanecarboxylic acids (c6Phe)

Avenoza, A.
París, M.
Peregrina, J.M.
Alías, M.
López, M.P.
García, J.I.
Cativiela, C.

January 2002

This report describes the synthesis and the conformational analysis of the optically pure dipeptides...

Conformationally Restricted Analogs of Antiaspartame-type Sweeteners

Formaggio, Fernando
M., Crisma
G., Valle
Toniolo, Claudio
W. H., J.
H. E., Schoemaker
J., Kamphuis
P. A., Temussi

January 1992

The synthesis and characterization of the two diastereomeric dipeptides Ac-L-(alphaMe)Phe-L-Lys-OH (...

Aspartame analogues containing 1-amino-2-phenylcyclohexanecarboxylic acids (c6Phe). Part 2

Alías, Miriam
Lasa, Marta
López, Pilar
García, José I.
Cativiela, Carlos

January 2005

This report describes the synthesis and conformational analysis of optically pure dipeptide analogue...

Conformation analysis of aspartame-based sweeteners by NMR spectroscopy, molecular dynamics simulations, and X-ray diffraction studies.

A. De Capua
M. Goodman
Y. Amino
M. Saviano
BENEDETTI, ETTORE

January 2006

We report here the synthesis and the conformation analysis by 1H NMR spectroscopy and computer simul...

Exploring the biological consequences of conformational changes in aspartame models containing constrained analogues of phenylalanine

Mollica, Adriano
Mirzaie, Sarra
Costante, Roberto
Carradori, Simone
Macedonio, G.
Dvorácskó, Szabolcs

January 2016

The dipeptide aspartame (Asp-Phe-OMe) is a sweetener widely used in replacement of sucrose by food i...

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

Samir H. Bouayad-Gervais
William D. Lubell

November 2013

The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitro...

Interaction of sweet proteins with their receptor - A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin

Tancredi T
Salvadori S
Esposito V
Temussi PA
PASTORE, ANNALISA

January 2004

The mechanism of interaction of sweet proteins with the T1R2-T1R3 sweet taste receptor has not yet b...

Conformation of Aminosuccinyl Dipeptides Ac-l-x-l-asu-nme From Empirical Energy Calculations

CAPASSO, SANTE
SICA, FILOMENA
C. A. MATTIA
L. MAZZARELLA
A. ZAGARI

January 1992

The aminosuccinyl (Asu) residue is formed as intermediate in some peptide and protein reactions. Pot...

Bioactive and Model Peptides Characterized By the Helicogenic (alpha-me)phe Residue

TONIOLO, CLAUDIO
FORMAGGIO, FERNANDO
M. CRISMA
G. VALLE
W. H. J.
H. E. SCHOEMAKER
J. KAMPHUIS
P. A. TEMUSSI
E. L. BECKER
G. PRECIGOUX

January 1993

We have synthesized and fully characterized the hypersweet super-aspartame analogue pCN-C6H4-NHCO-L-...

Synthesis and conformation of dipeptide taste ligands containing homo-B-amino acid residues

Abstract

Extracted data

Synthesis and conformation of dipeptide taste ligands containing homo-B-amino acid residues

Abstract

Extracted data

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