Increased High Mobility Group Box-1 protein levels are associated with impaired cardiopulmonary and echocardiographic findings after acute myocardial infarction.

Several markers of systemic inflammation appear to be active effectors in the pathophysiology of acute coronary syndrome and its evolution. High mobility group box-1 (HMGB-1), a ubiquitous nuclear protein constitutively expressed in quiescent cells, was recently recognized as a newer critical mediator of inflammatory diseases. The present study demonstrated that in postinfarction patient, HMGB-1 levels were significantly higher compared to healthy controls, and significantly correlated with cardiopulmonary and Doppler-echocardiography parameters