Polychlorinated biphenyls (PCB) are persistent environmental contaminants whose chronic exposure can affect nervous system development and function. The cellular and molecular mechanisms underlying neuronal damage are not yet clear. In the present study, we investigated whether nitric oxide (NO) could be involved in aroclor 1254 (A1254; a PCB mixture)-induced cytotoxicity in SH-SY5Y human neuroblastoma cells. Prolonged exposure (24 hr) to A1254 (10-100 microg/ml) caused a dose-dependent reduction of cell viability that was attenuated in the presence of a calcium entry blocker, gadolinum (Gd(3+)) at 10 microM, a concentration able to block voltage-sensitive calcium channels. In addition, A1254 caused an increase of cytosolic calcium that was...
Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefin...
Nitric oxide (NO) is a potent extracellular and intracellular physiological messenger. However, NO l...
Nitric oxide (NO) induces cell proliferation or cell death, depending on the cell type involved, the...
Polychlorinated biphenyls (PCB) are persistent environmental contaminants whose chronic exposure can...
Abstract. Polychlorinated biphenyls (PCB) are persistent environmental contaminants whose chronic...
Polychlorinated biphenyls (PCB) are persistent environ-mental contaminants whose chronic exposure ca...
In SH-SY5Y, a human neuroblastoma cell line, Aroclor 1254 (A1254), induced a dose-dependent (10-50 m...
Chronic exposure to polychlorinated biphenyls (PCBs), ubiquitous environmental contaminants, can adv...
Polychlorinated biphenyls (PCBs) are ubiquitous pollutants which accumulate in the food chain. Recen...
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs) are ...
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) are environmental pollutants that are well know...
Polychlorinated biphenyls (PCBs) are persistant organic pollutants that bioaccumulate and biomagnify...
Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefin...
Nitric oxide (NO) is a potent extracellular and intracellular physiological messenger. However, NO l...
Nitric oxide (NO) induces cell proliferation or cell death, depending on the cell type involved, the...
Polychlorinated biphenyls (PCB) are persistent environmental contaminants whose chronic exposure can...
Abstract. Polychlorinated biphenyls (PCB) are persistent environmental contaminants whose chronic...
Polychlorinated biphenyls (PCB) are persistent environ-mental contaminants whose chronic exposure ca...
In SH-SY5Y, a human neuroblastoma cell line, Aroclor 1254 (A1254), induced a dose-dependent (10-50 m...
Chronic exposure to polychlorinated biphenyls (PCBs), ubiquitous environmental contaminants, can adv...
Polychlorinated biphenyls (PCBs) are ubiquitous pollutants which accumulate in the food chain. Recen...
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and polybrominated diphenyl ethers (PBDEs) are ...
Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) are environmental pollutants that are well know...
Polychlorinated biphenyls (PCBs) are persistant organic pollutants that bioaccumulate and biomagnify...
Polychlorinated biphenyls (PCBs) cause a wide spectrum of toxic effects in the brain through undefin...
Nitric oxide (NO) is a potent extracellular and intracellular physiological messenger. However, NO l...
Nitric oxide (NO) induces cell proliferation or cell death, depending on the cell type involved, the...