Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic pharmacophore, related to clotrimazole, to develop innovative antimalarial agents. This study allowed us to discover compounds characterized by a high in vitro potency, particularly against Pf CQ-resistant strains selectively targeting free heme, which are easy to synthesize by low-cost synthetic strategie
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
We describe herein the design, synthesis, biological evaluation, and structure–activity relationship...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic pr...
The increasing resistance of the malaria parasite P. falciparum to currently available drugs demand...
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic pr...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
We report herein the generation and validation of a 3D-QSAR model based on a set of antimalarials pr...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
Identification of new molecular scaffolds structurally unrelated to known antimalarials may represen...
We describe herein the design, synthesis, biological evaluation, and structure–activity relationship...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic pr...
The increasing resistance of the malaria parasite P. falciparum to currently available drugs demand...
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic pr...
We describe herein the design, synthesis, biological evaluation, and structure-activity relationship...
We report herein the generation and validation of a 3D-QSAR model based on a set of antimalarials pr...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...
Malaria is a major health problem in poverty-stricken regions where new antiparasitic drugs are urge...