Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes
- Paneni, Francesco
- Costantino, Sarah
- Castello, Lorenzo
- Battista, Rodolfo
- Capretti, Giuliana
- Chiandotto, Sergio
- D'Amario, Domenico
- Scavone, Giuseppe
- Villano, Angelo
- Rustighi, Alessandra
- Crea, Filippo
- Pitocco, Dario
- Lanza, Gaetano Antonio
- Volpe, Massimo
- De Sal, Giannino
- Luscher, Thomas
- Cosentino, Francesco
Publication date
January 2014
DOIAbstract
Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease
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