Oral rehydration solution containing a mixture of non-digestible carbohydrates in the treatment of acute diarrhoea: a multicenter randomized placebo controlled study on behalf of the ESPGHAN Working Group on Intestinal Infections

HOEKSTRA JH
SZAJEWSKA H
ABU ZIKRI M
MICETIC TURK D
WEIZMAN Z
PAPADOPOULOU A
DIAS JA
OOSTVOGELS B.
GUARINO, ALFREDO

Publication date

January 2004

Abstract

OBJECTIVE: A randomized, double-blind, placebo-controlled multicenter study to evaluate efficacy and safety of a mixture of non-digestible carbohydrates (NDC) as an adjunct to oral rehydration therapy in treatment of acute infectious diarrhea in children with mild to moderate dehydration. METHODS: 144 boys aged 1 to 36 months with diarrhea defined as three or more watery stools per day for >1 day but <5 days with mild or moderate dehydration (World Health Organization criteria) were randomly assigned to receive hypotonic oral rehydration solution (ORS) (Na 60 mmol/L, glucose 111 mmol/L) with or without a mixture of NDC (soy polysaccharide 25%, alpha-cellulose 9%, gum arabic 19%, fructooligosaccharides 18.5%, inulin 21.5%, resistant starch ...