A key issue in designing applications codes which are able to effectively take advantage of grid computing environments is to deal and manage all the software components complexity, this is even more true for medical imaging applications. We are concerned with development of a medical imaging PSE for advanced and grid computing environments. Specifically, MedIGrid is a distributed application for the management, processing and visualization of biomedical images that integrates a set of software and hardware components, or, more specifically, a set of grid collaborative applications useful to nuclear doctors. It results from the interaction of computing scientists devoted to the design and deployment of new tomographic reconstruction algorit...