Add to ORKGThe present invention concerns compounds, some of which are novel, and their pharmaceutical applications. The compounds of the invention inhibit the enzyme lactate dehydrogenase (LDH) involved both in the metabolic process of hypoxic tumour cells, and in the process used by parasitic protozoa that cause malaria to obtain most of the energy they need
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD...
The present invention relates to compounds able to inhibit lactate dehydrogenase (LDH), to a process...
The present invention encompasses compounds able to inhibit the lactate production (lactic acid) inv...
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic g...
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic g...
Lactate dehydrogenase (LDH) inhibition is considered a worthwhile attempt in the development of inno...
The glycolysis is the stage of the production of energy by breakdown of glucose in body cells; a cha...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
Hypoxic tumours, normally resistant to chemotherapy and radiotherapy, are often characterized by a ...
Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
none4noIn the attempt of developing innovative anticancer treatments, growing interest has recently ...
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD...
The present invention relates to compounds able to inhibit lactate dehydrogenase (LDH), to a process...
The present invention encompasses compounds able to inhibit the lactate production (lactic acid) inv...
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic g...
In many different species, lactate dehydrogenase (LDH) constitutes a major checkpoint of anaerobic g...
Lactate dehydrogenase (LDH) inhibition is considered a worthwhile attempt in the development of inno...
The glycolysis is the stage of the production of energy by breakdown of glucose in body cells; a cha...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
Hypoxic tumours, normally resistant to chemotherapy and radiotherapy, are often characterized by a ...
Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with...
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-subst...
none4noIn the attempt of developing innovative anticancer treatments, growing interest has recently ...
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Lactate Dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate in the final step ...
Abstract Lactate dehydrogenase (LDH) catalyses the conversion of pyruvate to lactate and NADH to NAD...