Clinical effects of injectable collagen in lower-lid pretarsal fullness rejuvenation

Background: Lower-lid pretarsal fullness rejuvenation is a popular surgery for Asian women. However, the current procedures have clinical complications and are not stable in the long-term. Here, we analyzed the effect of injectable collagen on lower-lid pretarsal fullness rejuvenation. Methods: To investigate the clinical effect of injectable collagen in lower-lid pretarsal fullness rejuvenation, we observed 32 Chinese Han female patients aged 18–55 years with non-distinctive lower-lid pretarsal fullness and no history of lower eyelid surgery or trauma. The injectable collagen products were used for local filling correction. After surgery, the patients were followed up for 12 months. A correction effect was evaluated through an analysis of volume changes using a visual analog scale. Adverse reactions were also recorded. Results: All patients achieved good aesthetic outcomes and strong stereoscopic impressions of lower-lid pretarsal fullness. Complications, such as edema and bruising, were not observed after the injection. Immediately after the operation, the average visual analog score was 2.65 ​± ​0.56. Six months after the operation, the average visual analog score was 2.96 ​± ​0.41. The patients reported high satisfaction levels. Immediately after the operation, the average lower-lid pretarsal fullness volume increase was 0.19 ​± ​0.04 ​mL on the left side and 0.21 ​± ​0.03 ​mL on the right side. After a 12-month follow-up, the average residual volume was 0.17 ​± ​0.06 ​mL on the left side and 0.19 ​± ​0.04 ​mL on the right side, suggesting that the injected collagen impact was stable. Conclusion: Injectable collagen promotes a vivid, natural appearance and is highly effective in rejuvenating lower-lid pretarsal fullness with low absorption rates in later stages. Therefore, injectable collagen should be considered in correcting congenital, non-distinctive, lower-lid pretarsal fullness in clinical practice