Summary: Pain is driven by sensation and emotion, and in turn, it motivates decisions and actions. To fully appreciate the multidimensional nature of pain, we formulate the study of pain within a closed-loop framework of sensory-motor prediction. In this closed-loop cycle, prediction plays an important role, as the interaction between prediction and actual sensory experience shapes pain perception and subsequently, action. In this Perspective, we describe the roles of two prominent computational theories—Bayesian inference and reinforcement learning—in modeling adaptive pain behaviors. We show that prediction serves as a common theme between these two theories, and that each of these theories can explain unique aspects of the pain perceptio...
To cause pain, it is not enough to deliver a dose of noxious stimulation. Pain requires the interact...
Beliefs and expectations often persist despite evidence to the contrary. Here we examine two potenti...
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats rel...
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been consi...
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been consi...
Computational models of pain consider how the brain processes nociceptive information and allow mapp...
This paper aims to provide a theoretical framework for explaining the subjective character of pain e...
Computational models of pain consider how the brain processes nociceptive information and allow mapp...
This paper aims to provide a theoretical framework for explaining the subjective character of pain e...
Neural mechanisms underlying nociception and pain perception are considered to serve the ultimate go...
Neural mechanisms underlying nociception and pain perception are considered to serve the ultimate go...
Phenomena such as placebo analgesia or pain relief through distraction highlight the powerful influe...
The placebo effect is a component of any response to a treatment (effective or inert), but we still ...
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats rel...
Predicting that a stimulus is painful facilitates action to avoid harm. But how distinct are the neu...
To cause pain, it is not enough to deliver a dose of noxious stimulation. Pain requires the interact...
Beliefs and expectations often persist despite evidence to the contrary. Here we examine two potenti...
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats rel...
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been consi...
Since noxious stimulation usually leads to the perception of pain, pain has traditionally been consi...
Computational models of pain consider how the brain processes nociceptive information and allow mapp...
This paper aims to provide a theoretical framework for explaining the subjective character of pain e...
Computational models of pain consider how the brain processes nociceptive information and allow mapp...
This paper aims to provide a theoretical framework for explaining the subjective character of pain e...
Neural mechanisms underlying nociception and pain perception are considered to serve the ultimate go...
Neural mechanisms underlying nociception and pain perception are considered to serve the ultimate go...
Phenomena such as placebo analgesia or pain relief through distraction highlight the powerful influe...
The placebo effect is a component of any response to a treatment (effective or inert), but we still ...
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats rel...
Predicting that a stimulus is painful facilitates action to avoid harm. But how distinct are the neu...
To cause pain, it is not enough to deliver a dose of noxious stimulation. Pain requires the interact...
Beliefs and expectations often persist despite evidence to the contrary. Here we examine two potenti...
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats rel...