Perspectives on: In vitro evaluation of biomedical polymers

Recently polymeric materials have gained tremendous attention in a wide variety of applications spanning from electronics to environmental and biomedical fields. In this paper, current in vitro methods for polymers biocompatibility assessment are reviewed in combination with new concepts and techniques that appear promising for the development and improvement of in vitro methods with the purpose of reducing animal experimentation. The utilization of medical devices, for example, has always been subordinate to the assessment of their biocompatibility. This aspect, as well as the methods for evaluating biocompatibility have changed over the years as a result of new developments in cell biology that have revolutionized in vitro techniques for assaying polymeric materials for bioapplications