1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors
- Harmat NJS
- Di Bugno C
- Criscuoli M
- Giorgi R
- Lippi A
- Martinelli A
- Monti S
- Subissi A
DOIAbstract
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor. (C) 1998 Elsevier Science Ltd. All rights reserved
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