Ask
Search
My library

About
Statistics
Contact
Data Protection
Accessibility
Imprint
Changelog
Frontend: v1.31.3
Backend: v1.11.4

We use cookies to provide a better user experience.

Data Protection

A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus

Wang, G.
Sander, M.

Publication date

November 2021

DOI

10.1038/s41574-021-00556-4

Publisher

Springer Science and Business Media LLC

Abstract

Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) pathogenesis. However, human islet studies have revealed few consistent molecular changes in T2DM, owing partly to technical and biological confounding factors. A new multi-omics study of islets from well-phenotyped living donors attempts to overcome these limitations to catalogue T2DM-associated molecular changes

Extracted data

Related items

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

January 2018

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify tra...

Persistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetes

January 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Wigger, Leonore
Barovic, Marko
Brunner, Andreas-David
Marzetta, Flavia
Schöniger, Eyke
Mehl, Florence
Kipke, Nicole
Friedland, Daniela
Burdet, Frederic
Kessler, Camille
Lesche, Mathias
Thorens, Bernard
Bonifacio, Ezio
Legido-Quigley, Cristina
Barbier Saint Hilaire, Pierre
Delerive, Philippe
Dahl, Andreas
Klose, Christian
Gerl, Mathias J.
Simons, Kai
Aust, Daniela
Weitz, Jürgen
Distler, Marius
Schulte, Anke M.
Mann, Matthias
Ibberson, Mark
Solimena, Michele

January 2022

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Wigger, L.
Barovic, M.
Brunner, A.
Marzetta, F.
Schoeniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically ...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schoniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

January 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

The pancreatic β cell: recent insights from human genetics.

Thomsen, SK
Gloyn, AL

August 2014

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dys...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schöniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schöniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

The pancreatic β cell: recent insights from human genetics

Thomsen, Soren K.
Gloyn, Anna L.

August 2014

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dys...

Mining Genes in Type 2 Diabetic Islets and Finding Gold

Eizirik, Decio L.
Cnop, Miriam

November 2012

Pancreatic β cell failure is central in the pathogenesis of type 2 diabetes (T2D), but the mechanism...

Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

Jalal Taneera
Petter Storm
Leif Groop

January 2014

Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is un...

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Bacos, Karl
Perfilyev, Alexander
Karagiannopoulos, Alexandros
Cowan, Elaine
Ofori, Jones K
Bertonnier-Brouty, Ludivine
Rönn, Tina
Lindqvist, Andreas
Luan, Cheng
Ruhrmann, Sabrina
Ngara, Mtakai
Nilsson, Åsa
Gheibi, Sevda
Lyons, Claire L
Lagerstedt, Jens O
Barghouth, Mohammad
Esguerra, Jonathan Ls
Volkov, Petr
Fex, Malin
Mulder, Hindrik
Wierup, Nils
Krus, Ulrika
Artner, Isabella
Eliasson, Lena
Prasad, Rashmi B
Cataldo, Luis Rodrigo
Ling, Charlotte

January 2023

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. To identi...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

January 2018

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify tra...

Persistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetes

January 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Wigger, Leonore
Barovic, Marko
Brunner, Andreas-David
Marzetta, Flavia
Schöniger, Eyke
Mehl, Florence
Kipke, Nicole
Friedland, Daniela
Burdet, Frederic
Kessler, Camille
Lesche, Mathias
Thorens, Bernard
Bonifacio, Ezio
Legido-Quigley, Cristina
Barbier Saint Hilaire, Pierre
Delerive, Philippe
Dahl, Andreas
Klose, Christian
Gerl, Mathias J.
Simons, Kai
Aust, Daniela
Weitz, Jürgen
Distler, Marius
Schulte, Anke M.
Mann, Matthias
Ibberson, Mark
Solimena, Michele

January 2022

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Wigger, L.
Barovic, M.
Brunner, A.
Marzetta, F.
Schoeniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Wigger, Barovic and Brunner et al. perform a multidimensional analysis of islets from metabolically ...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schoniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

January 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

The pancreatic β cell: recent insights from human genetics.

Thomsen, SK
Gloyn, AL

August 2014

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dys...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schöniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes.

Wigger, L.
Barovic, M.
Brunner, A.D.
Marzetta, F.
Schöniger, E.
Mehl, F.
Kipke, N.
Friedland, D.
Burdet, F.
Kessler, C.
Lesche, M.
Thorens, B.
Bonifacio, E.
Legido-Quigley, C.
Barbier Saint Hilaire, P.
Delerive, P.
Dahl, A.
Klose, C.
Gerl, M.J.
Simons, K.
Aust, D.
Weitz, J.
Distler, M.
Schulte, A.M.
Mann, M.
Ibberson, M.
Solimena, M.

July 2021

Most research on human pancreatic islets is conducted on samples obtained from normoglycaemic or dis...

The pancreatic β cell: recent insights from human genetics

Thomsen, Soren K.
Gloyn, Anna L.

August 2014

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dys...

Mining Genes in Type 2 Diabetic Islets and Finding Gold

Eizirik, Decio L.
Cnop, Miriam

November 2012

Pancreatic β cell failure is central in the pathogenesis of type 2 diabetes (T2D), but the mechanism...

Downregulation of Type II Diabetes Mellitus and Maturity Onset Diabetes of Young Pathways in Human Pancreatic Islets from Hyperglycemic Donors

Jalal Taneera
Petter Storm
Leif Groop

January 2014

Although several molecular pathways have been linked to type 2 diabetes (T2D) pathogenesis, it is un...

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Bacos, Karl
Perfilyev, Alexander
Karagiannopoulos, Alexandros
Cowan, Elaine
Ofori, Jones K
Bertonnier-Brouty, Ludivine
Rönn, Tina
Lindqvist, Andreas
Luan, Cheng
Ruhrmann, Sabrina
Ngara, Mtakai
Nilsson, Åsa
Gheibi, Sevda
Lyons, Claire L
Lagerstedt, Jens O
Barghouth, Mohammad
Esguerra, Jonathan Ls
Volkov, Petr
Fex, Malin
Mulder, Hindrik
Wierup, Nils
Krus, Ulrika
Artner, Isabella
Eliasson, Lena
Prasad, Rashmi B
Cataldo, Luis Rodrigo
Ling, Charlotte

January 2023

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. To identi...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

July 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

January 2018

Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify tra...

Persistent or transient human β cell dysfunction induced by metabolic stress : specific signatures and shared gene expression with type 2 diabetes

January 2020

Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we assess whe...