REGIOCHEMICAL CONTROL OF THE RING-OPENING OF 1,2-EPOXIDES BY MEANS OF CHELATING PROCESSES .6. OPENING REACTIONS OF 3,4-EPOXYTETRAHYDROPYRAN

The regiochemical control of the ring opening of epoxides bearing polar remote functionalities, through chelation process assisted by metal ions, was verified in the title compound (4). The use of metal assisted procedures is several ring opening reactions of 4 leads to a modification of the regiochemical outcome, and the attack of the nucleophile on the C-4 oxirane carbon is highly favored