Sulfonamide synthesis via calcium triflimide activation of sulfonyl fluorides
- Ball, Nicholas
- Mukherjee, Paramita
- Woroch, Cristian P
- Cleary, Leah
- Rusznak, Mark
- Franzese, Ryan W
- Reese, Matthew R
- Tucker, Joseph W
- Humphrey, John M
- Etuk, Sarah M
- Kwan, Sabrina C
- Am Ende, Christopher W
DOIAbstract
A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield
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