Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort.
- Sullivan, Michael K
- Jani, Bhautesh Dinesh
- Lees, Jennifer S
- Welsh, Claire E
- McConnachie, Alex
- Stanley, Bethany
- Welsh, Paul
- Nicholl, Barbara I
- Lyall, Donald M
- Carrero, Juan-Jesus
- Nitsch, Dorothea
- Sattar, Naveed
- Mair, Frances S
- Mark, Patrick B
DOIAbstract
BACKGROUND: Multimorbidity [the presence of two or more long-term conditions (LTCs)] is associated with a heightened risk of mortality, but little is known about its relationship with the risk of kidney events. METHODS: Associations between multimorbidity and major adverse kidney events [MAKE: the need for long-term kidney replacement therapy, doubling of serum creatinine, fall of estimated glomerular filtration rate (eGFR) to <15 mL/min/1.73 m2 or 30% decline in eGFR] were studied in 68 505 participants from the UK Biobank cohort. Participants were enrolled in the study between 2006 and 2010. Associations between LTC counts and MAKE were tested using survival analyses accounting for the competing risk of death. RESULTS: Over a median follo...
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