Add to ORKGIn this paper we examine “gain of function” (GOF) research in virology, which results in a virus that is substantially more virulent or transmissible than its wild antecedent. We examine the typical animal model, the ferret, arguing that it does not easily satisfy potential desiderata for an animal model. We then discuss how these epistemic limitations bear on practical and policy questions around the risks and benefits of GOF research. We conclude with a reflection on how philosophy of science can contribute to policy discussions around the risks, benefits, and relative priority of particular life sciences research
Human influenza is a viral respiratory disease that often results in a high mor-bidity and considera...
In the twenty-first century, biology faces a problem that has previously vexed other disciplines suc...
© 2013 Dr. Kathryn Mary EdenboroughHighly pathogenic avian influenza A H5N1 viruses have caused more...
Gain-of-function research is research in which a virus or other pathogen is created, in the course o...
Influenza is a human pathogen that continues to pose a public health threat. The use of small mammal...
textabstractThe ferret transmission model is extensively used to assess the pandemic potential of em...
The ferret transmission model is extensively used to assess the pandemic potential of emerging influ...
Influenza virus infection of humans results in a respiratory disease that ranges in severity from su...
In recent years, scientists have engaged in a vigorous debate re-garding the value of so-called gain...
Lipsitch and Inglesby recently estimated the potential publichealth risks associated with research o...
Past pandemic influenza viruses with sustained human-to-human transmissibility have emerged from ani...
Influenza virus infections are a significant cause of morbidity and mortality in the human populatio...
The ferret transmission model is extensively used to assess the pandemic potential of emerging influ...
A transparent institutional review process will balance scientific freedom and national security bet...
ABSTRACT Inappropriately named gain-of-function influenza research seeks to confer airborne transmis...
Human influenza is a viral respiratory disease that often results in a high mor-bidity and considera...
In the twenty-first century, biology faces a problem that has previously vexed other disciplines suc...
© 2013 Dr. Kathryn Mary EdenboroughHighly pathogenic avian influenza A H5N1 viruses have caused more...
Gain-of-function research is research in which a virus or other pathogen is created, in the course o...
Influenza is a human pathogen that continues to pose a public health threat. The use of small mammal...
textabstractThe ferret transmission model is extensively used to assess the pandemic potential of em...
The ferret transmission model is extensively used to assess the pandemic potential of emerging influ...
Influenza virus infection of humans results in a respiratory disease that ranges in severity from su...
In recent years, scientists have engaged in a vigorous debate re-garding the value of so-called gain...
Lipsitch and Inglesby recently estimated the potential publichealth risks associated with research o...
Past pandemic influenza viruses with sustained human-to-human transmissibility have emerged from ani...
Influenza virus infections are a significant cause of morbidity and mortality in the human populatio...
The ferret transmission model is extensively used to assess the pandemic potential of emerging influ...
A transparent institutional review process will balance scientific freedom and national security bet...
ABSTRACT Inappropriately named gain-of-function influenza research seeks to confer airborne transmis...
Human influenza is a viral respiratory disease that often results in a high mor-bidity and considera...
In the twenty-first century, biology faces a problem that has previously vexed other disciplines suc...
© 2013 Dr. Kathryn Mary EdenboroughHighly pathogenic avian influenza A H5N1 viruses have caused more...