Multipoint linkage mapping of the Emery-Dreifuss muscular dystrophy gene.
- Kress W
- Müller E
- Kausch K
- Kullmann F
- Mostacciuolo ML
- Rietschel M
- Rotthauwe HW
- Schmalenberger B
- Siciliano G
- Voit T
- et al
Publication date
January 1992
DOI ISSN
0960-8966 Citation count (estimate)
11Abstract
The clinical features to establish the diagnosis of X-linked Emery-Dreifuss muscular dystrophy (EMD) were recently redefined at the European EMD workshop in Baarn 1991. These criteria were used to select families from the literature and two new families for linkage analysis with the DNA markers F9, DX52, DXS15, F8C and DXS115. Recombinations are observed with the DNA markers F9, DXS52 and DXS15. No recombinations were found with F8C and DXS115. Multipoint linkage analysis indicates with a maximum location score of 73.9 that the EMD locus maps very close to F8C
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