Add to ORKGThis thesis describes the generation of cell-of-origin based models, using mesenchymal stem cells, to further elucidate the underlying mechanism of molecular alterations of the bone-forming tumours osteoid osteoma, osteoblastoma and osteosarcoma. Furthermore, we describe the identification of novel treatment options for osteosarcoma using 2D and 3D in vitro models.</p
Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Ther...
As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were...
A number of solid tumours contains a distinct subpopulation of cells, termed cancer stem cells (CSCs...
This thesis describes the generation of cell-of-origin based models, using mesenchymal stem cells, t...
A mesenchymal stem cell (MSC) based osteosarcoma model was established. The model provided evidence ...
Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops ...
Osteosarcoma (OS) is the most common primary malignant tumor of bonethat mainly affects children and...
Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bone...
Biological models are necessary tools for gaining insight into underlying mechanisms governing compl...
High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of...
Bone sarcomas are rare tumour entities that arise from the mesenchyme most of which are highly heter...
Osteosarcoma is the commonest primary tumour of bone and the second highest cause of cancer-related ...
vulnerable to recurring disease and pulmonary metastases. Developing 3D in vitro disease models to s...
Ewing's sarcoma (ES) is a poorly differentiated pediatric tumor of aggressive behavior characterized...
We produced a novel three-dimensional (3D) bone tumor model (BTM) to study the interactions between ...
Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Ther...
As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were...
A number of solid tumours contains a distinct subpopulation of cells, termed cancer stem cells (CSCs...
This thesis describes the generation of cell-of-origin based models, using mesenchymal stem cells, t...
A mesenchymal stem cell (MSC) based osteosarcoma model was established. The model provided evidence ...
Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops ...
Osteosarcoma (OS) is the most common primary malignant tumor of bonethat mainly affects children and...
Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bone...
Biological models are necessary tools for gaining insight into underlying mechanisms governing compl...
High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of...
Bone sarcomas are rare tumour entities that arise from the mesenchyme most of which are highly heter...
Osteosarcoma is the commonest primary tumour of bone and the second highest cause of cancer-related ...
vulnerable to recurring disease and pulmonary metastases. Developing 3D in vitro disease models to s...
Ewing's sarcoma (ES) is a poorly differentiated pediatric tumor of aggressive behavior characterized...
We produced a novel three-dimensional (3D) bone tumor model (BTM) to study the interactions between ...
Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Ther...
As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were...
A number of solid tumours contains a distinct subpopulation of cells, termed cancer stem cells (CSCs...