Towards the Search for Potential Biomarkers in Osteosarcoma: State-of-the-Art and Translational Expectations
- Leonel Pekarek
- Basilio De la Torre-Escuredo
- Oscar Fraile-Martinez
- Cielo García-Montero
- Miguel A. Saez
- David Cobo-Prieto
- Luis G. Guijarro
- Jose V. Saz
- Patricia De Castro-Martinez
- Diego Torres-Carranza
- Tatiana Pekarek
- Ana Clara Carrera
- Melchor Alvarez-Mon
- Miguel A. Ortega
DOIAbstract
Osteosarcoma represents a rare cause of cancer in the general population, accounting for <1% of malignant neoplasms globally. Nonetheless, it represents the main cause of malignant bone neoplasm in children, adolescents and young adults under 20 years of age. It also presents another peak of incidence in people over 50 years of age and is associated with rheumatic diseases. Numerous environmental risk factors, such as bone diseases, genetics and a history of previous neoplasms, have been widely described in the literature, which allows monitoring a certain group of patients. Diagnosis requires numerous imaging tests that make it possible to stratify both the local involvement of the disease and its distant spread, which ominously determines...
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