Co-delivery of antimicrobials based on poly(D,L-lactic acid) 3D-scaffolds

Bone infection treatment is a clinical challenge, often complicated by simultaneous polymicrobial infections. A growing number of studies address the co-isolation of fungal and bacterial species, such as Candida albicans and Staphylococcus aureus, from polymicrobial biofilm associated with osteomyelitis. Recent publications demonstrate that scaffolds with local drug delivery ability, display high antimicrobial efficiency rates and reduced toxicity, suppressing the progression of bone disease and decreasing the number of pathogens in mono- or polymicrobial-biofilms.